I did some searching and wanted to pass on what I learned about protease enzymes. I didn’t find anything about digestive enzymes irritating an inflamed stomach. However, protease or proteolytic enzymes are also used between meals to reduce systemic inflammation or swelling from an injury. When used for that purpose, on an empty stomach, they can cause stomach pain. I think the specific protease enzymes used may also make a difference.
My digestive enzyme has proteases, and doesn’t bother my stomach, but of course we’re all very different.